EDI_infant = [ (FQ_htm × SA_hand × C_floor) + (C_resuspended × IR_breath × Hrs_active × DF_inhale) ] × Modifiers / BW
Evaluates hand-to-mouth ingestion and crawling resuspension. Modifiers account for particle size translocation. Final dose is normalized by Body Weight.
1. Infant Biometrics & Activity
Body Weight (BW) [kg]
Source: [WHO Child Growth Standards]Active Crawling (Hrs_active) [hr/day]
Source: [EPA ExpoBox - Infant Activity]Normalization Metric
Source: [Standard RA Practice vs. Particle-Specific]Using Body Weight is standard but may be less relevant for particle toxicology. 'None' provides the absolute particle flux.
2. Hand-to-Mouth Ingestion
Frequency (FQ_htm) [contacts/hr]
Source: [Xue et al. 2007 - Mouthing Frequencies]Hand Surface Area (SA_hand) [m²]
Source: [EPA Exposure Factors Handbook]Floor Dust Concentration (C_floor) [p/m²]
Source: [Zhang et al. 2023 - Indoor Microplastics]3. Resuspension Inhalation
Resuspended Dust Conc. (C_resus) [p/m³]
Source: [Wu et al. 2021 - Infant breathing zone]Active Breathing Rate (IR_breath) [m³/hr]
Source: [EPA - Infant short-term active]Inhaled Deposition Fraction (DF_inhale)
Source: [ICRP Respiratory Tract Model]4. Hazard Characterization
Note: High EDI is expected for this life stage due to intense crawling and hand-to-mouth behaviors. Adjust dust concentrations to model a cleaner environment.
Polymer & Chemical Profile
Source: [Lithner et al. 2011]Morphology & Size
Source: [Vethaak & Legler 2021]5. Risk Matrix Options