EDI_neonate = [ (Bottle_Load × Size_Modifier) + (C_dust × IR_breath_rest × 24hr × DF_inhale) ] / BW
Size modifier is applied only to the high-concern bottle pathway. Inhalation includes a deposition fraction. Final dose is normalized by Body Weight.
1. Neonatal Biometrics
Body Weight (BW) [kg]
Source: [WHO Child Growth Standards]Resting Breathing Rate (IR_breath) [m³/hr]
Source: [EPA Exposure Factors - Infant Resting]Normalization Metric
Source: [Standard RA Practice vs. Particle-Specific]Using Body Weight is standard but may be less relevant for particle toxicology. 'None' provides the absolute particle flux.
2. Formula Feeding Pathway
Bottle MNP Load (Bottle_Load) [particles/day]
Source: [Li et al. 2020 - PP Infant Feeding Bottles]This is the total daily particle load, not a concentration.
3. Ambient Inhalation (Crib Environment)
Ambient Dust Conc. (C_dust) [p/m³]
Source: [Vianello et al. 2019 - Indoor Air]Inhaled Deposition Fraction (DF_inhale)
Source: [ICRP Respiratory Tract Model]Fraction of inhaled particles deposited in the respiratory tract.
4. Hazard Characterization
Note: Defaults are set for a high-concern scenario (heated PP bottles). Adjust the Polymer Toxicity score if using alternative materials like glass.
Polymer & Chemical Profile
Source: [Lithner et al. 2011]Morphology & Size
Source: [Vethaak & Legler 2021]5. Risk Matrix Options